Organization of collecting duct intercalated cells
نویسندگان
چکیده
منابع مشابه
Collecting duct intercalated cell function and regulation.
Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. However, in recent years the understanding of the function of the intercalated cell has become greatly enhanced and has shaped a new model for how the distal segments of the kidney tubule integrate salt and water reabsorption, potassium homeostasis, and acid-base status. These ...
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BACKGROUND Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors. Although the location, concentration and roles of endogenous retinoic acid in post-natal kidneys are poorly defined, there is accumulating evidence linking post-natal vitamin A deficiency to impaired renal concentrating and acidifying ...
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1 2 August 3, 2012 3 Revised: August 6, 2012 4 5 Quantitative Phosphoproteomics in Nuclei of Vasopressin-Sensitive 6 Renal Collecting Duct Cells 7 8 9 Steven J. Bolger*, Patricia A. Gonzales Hurtado*, Jason D. Hoffert, Fahad Saeed, Trairak 10 Pisitkun, and Mark A. Knepper 11 12 *Co-First Authors 13 14 Epithelial Systems Biology Laboratory, 15 NHLBI, National Institutes of Health, 16 Bethesda, M...
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In the rat cortical collecting duct (CCD), the presence of highly specific receptors to calcitonin (CT) coupled to a sensitive adenylate cyclase system suggests that this segment is a target site for CT. Our aim was to explore the effects of CT on the rat CCD microperfused in vitro. The hormone failed to alter the osmotic water permeability and did not affect net Na+ transport but generated a l...
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The renal collecting duct (CD), as the terminal segment of the nephron, is responsible for the final adjustments to the amount of sodium excreted in urine. While angiotensin II modulates reabsorptive functions of the CD, the contribution of these actions to physiological homeostasis is not clear. To examine this question, we generated mice with cell-specific deletion of AT1A receptors from the ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1990
ISSN: 0085-2538
DOI: 10.1038/ki.1990.257